Targeted Microdosing for Precision Drug Development 

The MicroTex Hub is pioneering the development of new technologies to transform Intra-Target Microdosing (ITM) into a viable, efficient tool for accelerating drug discovery. ITM involves delivering minute quantities of a drug to a precisely targeted microscale region of the body—initially focusing on the lung and eye—so researchers can assess early signs of efficacy without systemic exposure. To make this possible, the project is creating high-precision delivery systems that enable reproducible, localised administration of microdoses. 

Next Generation Measurement and Imaging Tools 

To measure the effects of microdosing directly at the site of delivery, MicroTex is advancing a range of cutting-edge sensing and imaging technologies. These include optical fibre-based endoscopes, fluorescent smart probes, and implantable microsensors, all designed to provide real-time, high-resolution insight into therapeutic responses. By detecting biological signals such as inflammation, infection, or metabolic activity, these tools will help researchers make earlier, more informed decisions about which drug candidates are likely to succeed. 

Miniaturised Sensors and Technologies 

The project will also deliver a new generation of miniaturised electrochemical and optical sensors. These sensors will be able to detect a wide range of biomarkers—such as pH, enzyme activity, oxygen levels, and microbial presence—with high sensitivity and specificity. Platforms like smart contact lenses and dissolvable microneedle patches will be used to deliver drugs and monitor responses in the eye and skin, opening new opportunities for less invasive, patient-friendly diagnostics and treatments. 

Photonics and Light-Activated Therapies 

Building on the team’s expertise in photonics, MicroTex will develop advanced optical tools, including hollow-core fibres and ultrafast laser systems, to support both targeted therapy and high-precision imaging. These innovations will allow researchers to visualise tissues in detail and activate light-sensitive drugs exactly where needed, improving the safety and efficacy of experimental treatments. 

Microfabrication, Integration, and Computational Imaging 

Supporting these developments is a suite of microfabrication and micromechanical platforms for building and refining bespoke microscale tools. From nanoband electrode arrays to laser-fabricated components, these technologies will enable customisation and scalability of the ITM toolkit. Complementing the hardware will be advanced computational imaging and data integration systems designed to interpret the rich datasets produced during trials—ensuring robust analysis and streamlined decision-making in the drug development process.